Gut micobiota alteration by Lactobacillus rhamnosus reduces pro-inflammatory cytokines and glucose level in the adult model of Zebrafish

Abstract Objective Type 2 diabetes mellitus (T2DM) is still a challenge for physicians to manage patient’s circumstances. It assumed that alterations in the normal flora may be involved pathogenesis of T2DM through inducing chronic inflammation. To investigate effect Lactobacillus rhamnosus as common probiotic on T2DM, we induced an experimental model adult male Zebrafish by gradient hyper-glucose accumulation methodology. Results In this trial 3-month old were divided four groups including two control and with or without treatment. After 5 days acclimation, was Diabetic fishes had statistically abnormal blood glucose pro-inflammatory cytokine levels compared group (p = 0.0001). These results suggest intervention decreased level T2DM-P decreasing cytokines responsible signaling therapeutic modalities.